Adrenocorticotropic Hormone Fragment 4-10 human, rat

Xem hình lớn Code:A0401 Code: A0401 Đóng gói: 1mg, 5mg Hãng sản xuất: Sigma

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

Synonym: ACTH4-10

• CAS Number 4037-01-8

• Empirical Formula (Hill Notation) C₄₄H₅₉N₁₃O₁₀S

• Molecular Weight 962.09

•  MDL number MFCD00167482

•  PubChem Substance ID 24890423

  Properties

  Related Categories	Adrenocorticotropic Hormones (ACTH), Cell Biology, Cell Signaling and Neuroscience, Peptides and Proteins, Peptides for Cell Biology
  assay	≥97% (HPLC)
  storage temp.	−20°C
  Gene Information	human ... POMC(5443) rat ... Crhr2(64680)

  Description

  Amino Acid Sequence

  Met-Glu-His-Phe-Arg-Trp-Gly

  Other Notes

  Core fragment of ACTH, α- and β-MSH, and β-lipotropin

  Packaging

  Bottomless glass bottle. Contents are inside inserted fused cone.

  Quality

  Lacks adrenocorticotropic activity.

  Biochem/physiol Actions

  Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.

  Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.